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Sedaqat M. Relationship between major depressive disorder and inflammatory bowel disease: prevalence, mechanisms, and clinical outcomes. KJMS 2024; 9 (15) :43-50
URL: http://kjms.knu.edu.af/article-1-51-en.html

Major Depressive Disorder (MDD) is a common complication in patients with Inflammatory Bowel Disease (IBD) that significantly impacts their quality of life and disease management. This review study examines articles published from 2010 to 2024, focusing on the prevalence, pathophysiological mechanisms, and clinical implications of MDD in IBD patients. A systematic search was conducted across multiple databases, identifying studies that highlighted the relationship between IBD and MDD. The findings indicate that the prevalence of depression in IBD patients is higher than that in the general population, with inflammatory pathways and psychosocial factors contributing to this condition. Effective screening and integrated treatment approaches are essential for improving patient outcomes. This study emphasizes the importance of addressing mental health in the management of patients with IBD.