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Mousavi S Y, Bayat A. Alzheimer's Disease and the Beta Amyloid: A review of animal studies. KJMS 2025; 9 (18) :1-10
URL: http://kjms.knu.edu.af/article-1-59-en.html

Introduction: Loss of ability to perform daily activities, impairment of cognition and memory impairments are the clinical symptoms of Alzheimer's disease (the most common form of dementia). There are two neuropathological signs for diagnosis of Alzheimer's disease: 1. extracellular deposition of peptide A; 2. accumulation of phosphorylated tau in neurofibrillary tangles in neurons. Beta Amyloid that originally called A4 amyloid protein, is one of the most important insoluble brain peptides studied in neuroscience.
Methods: The data of this study were collected from original and scientific articles published in databases such as PubMed, Science Direct, Web of Science, Scopus, and Google Scholar and were included in the study based on the eligibility criteria.
Results: In this review study, 3 main articles of experimental animal studies that are about the effect of beta-amyloid on Alzheimer's disease were investigated. The findings showed that beta-amyloid deposited in different areas of the brain and causes various disorders. Beta-amyloid in different doses has different effects on the brain. The increase in amyloid levels can have various reasons.
Conclusion: The results obtained from these studies showed that the effects of beta amyloid are dose-dependent and dependent on the frequency of intrahippocampal injection, and we can point to that it causes tissue destruction and reduced enzyme activity in different brain areas.